hATTR amyloidosis – could you be at risk?
ABOUT hATTR AMYLOIDOSIS
hATTR amyloidosis is a serious but treatable condition. It is a rare disease and very difficult to diagnose. In fact, misdiagnosis is common and it can often take patients several years from symptom onset to get the right diagnosis and start treatment. Determining if you are at risk can help speed up this process.
WHO IS AT RISK?
hATTR amyloidosis is a genetic disease that is passed down through family members.
Individuals of Portuguese descent are at a higher risk of inheriting this rare disease than most other people.
If you have symptoms of hATTR amyloidosis or if it runs in your family, genetic testing is a crucial step in getting correctly diagnosed.
Ask your doctor for more information about genetic testing for hATTR amyloidosis.
Bilateral carpal tunnel syndrome*
- Pain and numbness or tingling in the wrists and hands caused by disturbances in nerve function
Weakness, numbness and pain from nerve damage (peripheral sensory-motor neuropathy)
- Nerve damage beginning in the hands and feet that can progress to the central part of the body
- Difficulty walking
Symptoms related to the eyes, often causing visual changes
- Dark floaters (spots in your vision)
- Glaucoma (can lead to vision loss or blindness)
- Eyelid swelling and inflammation
- Abnormal blood vessels in the eye
- Nausea and vomiting
- The inability to eat a full meal or feeling full after only a small amount of food
- Severe constipation
- Alternating episodes of diarrhea/constipation
- Unintentional weight loss
Symptoms related to the heart, blood vessels and circulation
- Irregular heartbeat
- Delay or blockage of the electrical signals in the heart
- Cardiomyopathy (disease of the heart muscle)
- Thickening of heart muscle
- Pain, tingling or numbness of lower extremities caused by nerve compression in the spine due to narrowing of the spinal canal
Damage to the nerves that control internal organs (autonomic neuropathy)
- Sexual dysfunction
- Sweating abnormalities
- Dizziness upon standing after sitting or lying down caused by low blood pressure
- Recurrent urinary tract infections (due to urinary retention)
- Kidney failure
- Protein in urine (foamy, frothy or bubbly-looking urine)